Association between abdominal obesity and asthma: a meta-analysis

Review - Open Access
Di JiangLiwen WangChenxiao Bai and Ou Chen Email authorView ORCID ID profile

Abstract

Background

Studies evaluating the association between abdominal obesity and asthma yielded conflict results. Whether abdominal obesity is positively associated with asthma remains unclear.

Objective

To quantitatively determine the association between abdominal obesity and asthma.

Methods

Databases including PubMed, Web of Science, China National Knowledge Infrastructure, China Biology Medicine disc, Chinese Scientific and Technological Journal Database and Wanfang Data were searched up to February 2018 to collect all relevant studies. Reference lists of related articles were also checked. After study selection and data extraction, meta-analysis was conducted to calculate the pooled odds ratio (OR) and corresponding 95% confidence interval (CI). Subgroup analyses by study design and age groups of participants were further performed. Publication bias was assessed via Begg’s rank correlation and Egger’s linear regression methods.

Results

A total of 13 studies were included in the final meta-analysis, including 2 case–control studies, 6 cohort studies, and 5 cross-sectional studies. Our meta-analysis observed a positive association between abdominal obesity and asthma (OR = 1.47, 95% CI 1.35–1.59). No evidence of heterogeneity (I2 = 10.7%) or publication bias (Begg’s test P = 0.200, Egger’s test P = 0.146) was found. Subgroup analyses by study design and age groups of participants obtained consistently positive results across subgroups. Moreover, our meta-analysis observed similar results when considering this association separately in males and females (Males: OR = 1.37, 95% CI 1.18–1.58; Females: OR = 1.39, 95% CI 1.22–1.58). In addition, the association between abdominal overweight and asthma was further explored in this meta-analysis and the pooled OR and 95% CI was 1.13 (1.03, 1.24), indicating that there is a dose–response relationship between abdominal weight status and asthma.

Conclusions

Our meta-analysis shows a positive association between abdominal obesity and asthma. Moreover, this association is similar in males and females. In addition, our meta-analysis indicates that there is a dose–response relationship between abdominal weight status and asthma. Therefore, addressing abdominal obesity issue is of great importance. More studies are needed in the future to clarify the association between abdominal obesity and asthma.

Download PDF

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma RT @Aller_MD: Egg Allergy? Don't Let That Stop You From Getting Vaccinated https://t.co/0ZBe68O1fa
6hreplyretweetfavorite
Interasma Top story: Marijuana Cannabis Allergy https://t.co/c4bzRhT0oj, see more https://t.co/CpGiFuOOYd
9hreplyretweetfavorite
Interasma RT @Aller_MD: Top story: Marijuana Cannabis Allergy https://t.co/dEin0Cq9kK, see more https://t.co/jgCeENQuZt
14hreplyretweetfavorite
Interasma RT @Aller_MD: Decline in measles vaccination is causing a preventable global resurgence of the disease https://t.co/fHQXw8Fwrk
14hreplyretweetfavorite
Interasma RT @Aller_MD: Discovery may help explain why women get autoimmune diseases far more often than men https://t.co/s1aSxX9mTW
14hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma