Pharmacokinetics and pharmacodynamics of monoclonal antibodies for asthma treatment

Review

Expert Opinion on Drug Metabolism & Toxicology, 15:2,113-120, DOI: 10.1080/17425255.2019.1568409
 

Introduction: Asthma is a chronic inflammatory airway disease. It occurs in a ‘severe’ form in about 8–10% of asthmatic patients. In the last decade, the development of biological drugs (e.g. monoclonal antibodies) allowed to efficiently approach severe asthma. The current therapeutic targets available are mainly those related to TH2 inflammation.

Areas covered: The main pharmacokinetic and pharmacodynamic characteristics of the monoclonal antibodies against IL-5, IL-5Ra, IL4-IL13, and IgE, that are currently marketed or understood for severe asthma are discussed in this paper.

Expert opinion: The currently available biological drugs represent an excellent therapeutic add-on to traditional drugs, especially in replacing systemic corticosteroid therapies. The different pharmacokinetic and pharmacodynamic characteristics of the drugs, despite sometime sharing the same target, would allow a better personalization of the therapy, tailoring the treatment to the characteristics of the patient.

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma RT @Aller_MD: Egg Allergy? Don't Let That Stop You From Getting Vaccinated https://t.co/0ZBe68O1fa
6hreplyretweetfavorite
Interasma Top story: Marijuana Cannabis Allergy https://t.co/c4bzRhT0oj, see more https://t.co/CpGiFuOOYd
9hreplyretweetfavorite
Interasma RT @Aller_MD: Top story: Marijuana Cannabis Allergy https://t.co/dEin0Cq9kK, see more https://t.co/jgCeENQuZt
14hreplyretweetfavorite
Interasma RT @Aller_MD: Decline in measles vaccination is causing a preventable global resurgence of the disease https://t.co/fHQXw8Fwrk
14hreplyretweetfavorite
Interasma RT @Aller_MD: Discovery may help explain why women get autoimmune diseases far more often than men https://t.co/s1aSxX9mTW
14hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma