Immunotherapy and Asthma in Children

MINI REVIEW ARTICLE

Maria A. Tosca1*Amelia Licari2Roberta Olcese1Gianluigi Marseglia2Oliviero Sacco3 and Giorgio Ciprandi4
1Department of Pediatrics, Allergy Center, Istituto Giannina Gaslini (IRCCS), Genoa, Italy
2Department of Pediatrics, Ospedale San Matteo (IRCCS), Pediatrics Clinic, University of Pavia, Pavia, Italy
3Pediatric Pulmonology and Endoscopy, Istituto Giannina Gaslini (IRCCS), Genoa, Italy
4Allergy Clinic, Ospedale San Martino (IRCCS), Genoa, Italy

Allergen immunotherapy (AIT) is still the only disease-modifying treatment strategy for IgE-mediated allergic diseases, with consolidated evidence both in adults and children. AIT is effective in determining clinical improvement of allergic rhinitis and asthma, such as reduced symptoms, medication use, and improvement of quality of life, with a long-lasting effect after cessation of treatment. Results from recent clinical studies have implemented the evidence of effectiveness and safety of allergen immunotherapy for the treatment of allergic asthma, so that the current asthma guidelines now recommend sublingual immunotherapy as an add-on therapy for asthma in adults and adolescents with house dust mite allergy, allergic rhinitis, and exacerbations despite low-to-moderate dose ICS, with forced expiratory volume in 1 second more than 70% predicted. AIT may also reduce the risk of progression from allergic rhinitis to asthma in children and prevent the onset of new sensitizations, thus representing a potentially preventive method of treatment. The aim of this review is to present an updated overview of the clinical indications of AIT, with particular reference to pediatric asthma, of the mechanisms of clinical and immunological tolerance to allergens, and of the potential biomarkers predicting clinical response.


Download Article

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma RT @Aller_MD: Subcutaneous immunotherapy induces alterations in monocytes and dendritic cells homeostasis in allergic rhinitis patients htt…
1hreplyretweetfavorite
Interasma RT @Aller_MD: Top story: @SeattleMamaDoc: '“Air Canada doesn’t have epi on board” (apparently too expensive - huh). Thankfully most food-al…
1hreplyretweetfavorite
Interasma Interasma - Effects of Macrolide Treatment during the Hospitalization of Children with Childhood Wheezing Disease:… https://t.co/XLMhnvQl5E
3hreplyretweetfavorite
Interasma RT @ARIAGuideline: Towards precision medicine in chronic rhinosinusitis. Prof. Dr. Benjamin Bleier, USA. https://t.co/ps5LKfOD6H
8hreplyretweetfavorite
Interasma RT @ARIAGuideline: First-line and second-line treatments for chronic sinusitis. An interview with Prof. Peter Hellings, Belgium https://t.c…
8hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma