Type 2 immunity in asthma

 
Marco Caminati, Duy Le Pham, Diego Bagnasco and Giorgio Walter Canonica
 
World Allergy Organization Journal 2018 11:13

https://doi.org/10.1186/s40413-018-0192-5

Abstract

Type 2-immunity represents the typical adaptive response to allergen exposure in atopic individuals. It mainly involves Th2 cells and immunoglobulin E, as the main orchestrators of type 2-inflammation. Recently, it has been highlighted that allergens may be responsible for a Th2 response beside specific IgE activation and that a number of other environmental stimuli, such as viruses and pollutants, can trigger the same pattern of inflammation beyond atopy. Emerging data sustain a substantial role of the so-called epithelial dysfunction in asthma pathogenesis, both from anatomic and functional point of view. Furthermore an increasing amount of evidence demonstrates the relevance of innate immunity in polarizing a Th2 impaired response in asthmatic patients. Under this perspective, the complex cross-talking between airway epithelium, innate and adaptive immunity is emerging as a major determinant of type 2-inflammation beyond allergens.

This review will include an update on the relevance of dysregulation of innate and adaptive type 2-immunity in asthma pathogenesis, particularly severe asthma, and on the role of the allergens that are associated with severe asthma. Type 2-immunity also will be reviewed in the light of the current and upcoming targeted treatments for severe asthma.

Download PDF

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma Top story: Data Sharing Report | Asthma UK https://t.co/LjNWghYL44, see more https://t.co/CpGiFuOOYd
14hreplyretweetfavorite
Interasma RT @AllergyEaaci: Advances in managing COPD related to α1‐antitrypsin deficiency: An under‐recognized genetic disorder. Download Article He…
15hreplyretweetfavorite
Interasma RT @Aller_MD: My Tweeted Times https://t.co/36WLWcQjoy - top stories by @GavinPrestonMD, @CleanAirLondon
15hreplyretweetfavorite
Interasma RT @Aller_MD: NIH, Children's National Health System join forces to study pediatric disease https://t.co/vdbhviWhMF
15hreplyretweetfavorite
Interasma RT @eaaci_patients: AAAAI & EAACI answer your questions on asthma and air quality. Save the date and join the Twitter chat on 27 September…
15hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma