A simple prediction tool for inhaled corticosteroid response in asthmatic children

Yi-Fan WuMing-Wei SuBor-Luen ChiangYao-Hsu YangChing-Hui Tsai and Yungling L. Lee
BMC Pulmonary Medicine
BMC series – open, inclusive and trusted 2017 17:176

https://doi.org/10.1186/s12890-017-0533-0

Abstract

Background

Inhaled corticosteroids are recommended as the first-line controller medication for childhood asthma owing to their multiple clinical benefits. However, heterogeneity in the response towards these drugs remains a significant clinical problem.

Methods

Children aged 5 to 18 years with mild to moderate persistent asthma were recruited into the Taiwanese Consortium of Childhood Asthma Study. Their responses to inhaled corticosteroids were assessed based on their improvements in the asthma control test and peak expiratory flow. The predictors of responsiveness were demographic and clinical features that were available in primary care settings. We have developed a prediction model using logistic regression and have simplified it to formulate a practical tool. We assessed its predictive performance using the area under the receiver operating characteristic curve.

Results

Of the 73 asthmatic children with baseline and follow-up outcome measurements for inhaled corticosteroids treatment, 24 (33%) were defined as non-responders. The tool we have developed consisted of three predictors yielding a total score between 0 and 5, which are comprised of the following parameters: the age at physician-diagnosis of asthma, sex, and exhaled nitric oxide. Sensitivity and specificity of the tool for prediction of inhaled corticosteroids non-responsiveness, for a score of 3, were 0.75 and 0.69, respectively. The areas under the receiver operating characteristic curve for the prediction tool was 0.763.

Conclusions

Our prediction tool represents a simple and low-cost method for predicting the response of inhaled corticosteroids treatment in asthmatic children.

Download PDF

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma RT @Aller_MD: Top story: @MatthewBowdish: 'Castro: Site of action of targeted therapies for s… https://t.co/M5derssa15, see more https://t.…
2hreplyretweetfavorite
Interasma RT @Aller_MD: “Regeneron (REGN) Reports Approval of DUPIXENT in Japan for Treatment of Atopic Dermatitis” https://t.co/kUdtuobA6v https://t…
2hreplyretweetfavorite
Interasma RT @Aller_MD: Bilastine Newsletter - Discover what´s new in allergy and antihistamines https://t.co/GmJQkUOBIO https://t.co/5pz0xYFzYJ
5hreplyretweetfavorite
Interasma RT @Aller_MD: “Guideline: Experts recommend a single dose of oral steroids for pain relief in acute sore throat” https://t.co/DnEFi1FiCX ht…
5hreplyretweetfavorite
Interasma RT @Aller_MD: Beneficial bacteria on the skin of mice promotes immunity and accelerates wound healing https://t.co/XNFdTCZvsi
5hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma