The environment, epigenome, and asthma

Abstract

Asthma prevalence has been on the increase, especially in North America compared with other continents. However, the prevalence of asthma differs worldwide, and in many countries the prevalence is stable or decreasing. This highlights the influence of environmental exposures, such as allergens, air pollution, and the environmental microbiome, on disease etiology and pathogenesis. The epigenome might provide the unifying mechanism that translates the influence of environmental exposures to changes in gene expression, respiratory epithelial function, and immune cell skewing that are hallmarks of asthma. In this review we will introduce the concept of the environmental epigenome in asthmatic patients, summarize previous publications of relevance to this field, and discuss future directions.

PDF (1 MB)

Full Text

 

 

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma RT @Aller_MD: Top tips on getting through hot weather with hay fever https://t.co/ab0jHLpZBM
2hreplyretweetfavorite
Interasma RT @Aller_MD: FDA investigating unauthorized herpes vaccine research https://t.co/47Tk96Bjpb
2hreplyretweetfavorite
Interasma RT @Aller_MD: Children with low-risk penicillin #allergy symptoms who tested negative for penicillin allergy tolerated penicillin without s…
2hreplyretweetfavorite
Interasma RT @Aller_MD: By assessing the industry- and occupation-specific prevalence of asthma, this report aims to assist physicians to identify wo…
6hreplyretweetfavorite
Interasma RT @Aller_MD: Although allergies might seem a world away from mental health, a new study finds that common allergic conditions increase the…
6hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma