Specific allergen immunotherapy for the treatment of allergic asthma: a review of current evidence.

J Investig Allergol Clin Immunol. 2017 Jun;27(Suppl. 1):1-352

Authors: Dominguez-Ortega J, Delgado J, Blanco C, Prieto L, Arroabarren E, Cimarra M, Henriquez-Santana A, Iglesias-Souto J, Vega-Chicote JM, Tabar AI

Abstract
Asthma is frequently associated with atopy, characterized by the production of specific immunoglobulin E in response to environmental allergens. Currently, two types of allergen immunotherapy (AIT) are used in clinical practice: subcutaneous and sublingual immunotherapy, both accepted as key components of the therapeutic repertoire for allergic rhinitis and conjunctivitis. However, their role in asthma remains controversial. The present document is aimed at providing the clinicians with a review of the evidence on the use of AIT in asthma, focusing on the most relevant aspects of its mechanism of action, its efficacy, and existing data on safety, tolerability, and cost-effectivity, both in pediatric and adult populations. A systematic search of MEDLINE, Cochrane, and Clinical Trials databases from 2000 to April of 2016 was carried out by a panel of experts from the Spanish Allergy and Clinical Immunology Scientific Society. Relevant studies prior to the year 2000 included in ulterior systematic reviews were also considered. More than 4000 articles were identified during the search and 241 were selected to retrieve available evidence on AIT, which was graded according to the Oxford classification. All the group members reviewed the resulting text until the final version reached the consensual agreement. A summary of recommendations on the more relevant topics are proposed. The role of AIT as a valuable therapeutic strategy for prevention of exacerbation and progressive decline in lung function is highlighted. Future research should include specific tools for asthma evaluation when assessing AIT effectiveness in asthmatic patients.

[PDF full-Text]

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma Top story: Sarah B D on Twitter: "@picardonhealth I got the flu shot because I’… https://t.co/PKYRRO1cxM, see more https://t.co/CpGiFuOOYd
1hreplyretweetfavorite
Interasma Top story: Rae Brager on Twitter: "@DrAnneEllis Also decrease REM sleep and the… https://t.co/fy2uqXrC3v, see more https://t.co/CpGiFuOOYd
3hreplyretweetfavorite
Interasma Top story: Dr. Ellis on Twitter: "Rupatadine also low/moderate potential for in… https://t.co/RZVJTybrxF, see more https://t.co/CpGiFuOOYd
11hreplyretweetfavorite
Interasma Top story: Dr. Winder Gill on Twitter: "I'd like to do a poll of how many medic… https://t.co/DCyPZUyIAr, see more https://t.co/CpGiFuOOYd
13hreplyretweetfavorite
Interasma Top story: Salt raises blood pressure, but our gut bacteria can stop it https://t.co/4l5nkVGpC6, see more https://t.co/CpGiFuOOYd
15hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma