Acute Radiological Abnormalities after Bronchial Thermoplasty: A Prospective Cohort Trial

S. Karger AG
Clinical Investigations
Open Access Gateway
d'Hooghe J.N.S.a · van den Berk I.A.H.b · Annema J.T.a · Bonta P.I.a 

 Author affiliations

Abstract

Background: Bronchial thermoplasty (BT) is a novel treatment for severe asthma based on radiofrequency energy delivery to the larger airways. Although impressive radiological abnormalities have been reported, the incidence, pattern, and behavior over time of acute radiological abnormalities following BT are not well established. Objective: To assess the incidence pattern and behavior over time of acute radiological abnormalities following BT. Methods: This is a prospective, observational imaging study of severe asthma patients participating in the TASMA trial. Imaging of the lung (chest X-ray and/or computed tomography [CT]) was performed routinely before and directly after BT, within 6 weeks and at 6 months' follow-up. Results: Thirty-four chest X-rays were performed within <5 h following 34 BT procedures in 12 patients. In 91% of cases, radiological abnormalities were seen, designated as peribronchial consolidations (97%) and/or atelectasis (29%). Ultra-low-dose (ULD) chest CTs were performed following 16 BT procedures showing abnormalities in all. Four different radiological patterns were identified: peribronchial consolidations with surrounding ground glass opacities (94%), atelectasis (38%), partial bronchial occlusions (63%), and bronchial dilatations (19%). No bronchoscopic intervention was needed. At 6 months' follow-up, in a single patient, high-resolution chest CT showed a focal bronchiectasis in a single airway. Conclusions: There is a high incidence of acute radiological abnormalities after BT. Four distinct radiological patterns can be identified on ULD chest CT, which resolve without clinical impact in virtually all cases.

FullText PDF

(You must be logged in to add and reply comments)

Interasma on Twitter

Interasma RT @Aller_MD: Top story: @MatthewBowdish: 'Castro: Site of action of targeted therapies for s… https://t.co/M5derssa15, see more https://t.…
2hreplyretweetfavorite
Interasma RT @Aller_MD: “Regeneron (REGN) Reports Approval of DUPIXENT in Japan for Treatment of Atopic Dermatitis” https://t.co/kUdtuobA6v https://t…
2hreplyretweetfavorite
Interasma RT @Aller_MD: Bilastine Newsletter - Discover what´s new in allergy and antihistamines https://t.co/GmJQkUOBIO https://t.co/5pz0xYFzYJ
5hreplyretweetfavorite
Interasma RT @Aller_MD: “Guideline: Experts recommend a single dose of oral steroids for pain relief in acute sore throat” https://t.co/DnEFi1FiCX ht…
5hreplyretweetfavorite
Interasma RT @Aller_MD: Beneficial bacteria on the skin of mice promotes immunity and accelerates wound healing https://t.co/XNFdTCZvsi
5hreplyretweetfavorite

Editor: Juan C. Ivancevich, MD

Copyright © Interasma 2003-2017  •  Terms of Use  •  Privacy Policy  •  Contact Us  •  Sitemap

Powered by FREI SA

InterAsma